| abstract |
The invention relates to the field of medicinal chemistry, five-membered and six-membered aza-heteroaromatic compounds, a preparation method thereof, a medicinal composition and applications thereof. Specifically, it relates to a class of compounds having the ability to specifically enhance the ubiquitination and degradation of Ras proteins, a preparation method thereof, a pharmaceutical composition comprising the compounds, and the preparation of these compounds for prevention or treatment and in vivo related to Ras activity Use in the medicine of the disease, especially in the preparation of the medicine for the prevention or treatment of tumor growth and metastasis. |