http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110862546-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 |
| filingDate | 2019-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110862546-B |
| titleOfInvention | Methotrexate metal coordination polymer and preparation method and application thereof |
| abstract | The invention discloses a methotrexate metal coordination polymer and a preparation method and application thereof, and the structural formula is as follows: wherein R is functional metal ion. The invention introduces Gd capable of being imaged by MRI into the structure of MTX III And Fe III Obtaining MTX-Gd III And MTX-Fe III The coordination polymer can be efficiently delivered to folate receptor over-expressed tumor cells under the mediation of active targeting (MTX has strong affinity with folate receptor), so that the administration dosage is reduced, and accurate and efficient diagnosis and treatment of tumor lesions are realized; by introducing Zn with immune promoting effect into the structure of MTX II Obtaining MTX-Zn II Coordination polymers, which are expected to be highly effective in treating tumors and immune diseases. |
| priorityDate | 2019-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.