http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110862339-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1fefd66fdbc3870bbaa8e5a4f87bdb0a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d80c5935b7f98a391fdd71fbc988dd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_488535fab7cc33477a4af661530db27b |
| publicationDate | 2020-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110862339-A |
| titleOfInvention | A kind of indole small molecule compound and preparation method thereof |
| abstract | The invention belongs to the technical field of medicine, and discloses an indole-type small molecule compound with antitumor activity and a preparation method thereof. Compound V and compound VI are sequentially dissolved in an organic solvent at room temperature, then alkali is added and stirred for a while; Oxidant, after the reaction is completed, add a small amount of water to quench the reaction, then extract with ethyl acetate; wash with water and saturated brine, and dry the organic phase with anhydrous sodium sulfate; finally filter, concentrate, and separate by column chromatography to obtain the target compound IV. The invention adopts cheap and readily available C2-substituted indole and carbonyl compound to undergo oxidative coupling under alkaline conditions; the functional group tolerance is good, the reaction is simple, and the atom and step economy is good; and a complex indole small molecule library can be rapidly constructed. In addition, the novel indole small molecule prepared by the invention has the characteristics of "drug-like molecule" in structure, has considerable anti-tumor activity and certain anti-tumor drug resistance, and can be used as a leading compound for drug development. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113200984-A |
| priorityDate | 2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 134.