| abstract |
The invention belongs to the field of pharmaceutical preparations, and in particular relates to a nano-suspension of isoliquiritigenin and a preparation method and application thereof. 1:0.1～10, particle size is 200～700nm, potential is ‑30mV～20mV; the space stabilizer is hydroxypropyl cellulose, povidone K30, hydroxypropyl methylcellulose, polyethylene glycol 6000 , one or more of vitamin E polyethylene glycol succinate and croscarmellose sodium. The isoliquiritigenin nanosuspension has high drug loading and good stability, and the cumulative dissolution rate and dissolution rate are also significantly improved. In vitro cell experiments show that compared with the isoliquiritigenin bulk drug, the ability to induce apoptosis in lung cancer A549 cells is significantly improved. Its ability to be taken up by tumor cells and inhibit the proliferation of cancer cells is also significantly enhanced, providing a new idea for improving the solubility and anti-tumor activity of poorly soluble drugs. |