http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110845579-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-32 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-62 |
| filingDate | 2019-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110845579-B |
| titleOfInvention | Polymyxin E component and photochemical product thereof and liquid chromatography-mass spectrometry analysis method |
| abstract | The invention discloses a Polymyxin E (Polymyxin E, PME) component and a photochemical product thereof and a liquid chromatography-mass spectrometry analysis method; the polymyxin E component comprises a polymyxin E double-bonded component, specifically comprises a polymyxin E1 double-bonded component and a polymyxin E2 double-bonded component, and the double bonds of the components are verified to be positioned at the tail end of an N-fatty acyl chain through high performance liquid chromatography-mass spectrometry (HPLC-MS) and secondary mass spectrometry. The double-bonded component is subjected to photochemical reaction, namely, a Patinophiki reaction (in) under the condition that acetone is used as a reaction reagent Reaction) to obtain photochemical products, which are verified as [2+2] by HPLC-MS]A cycloaddition product; the double-bonded components are named 7 '-alkenyl polymyxin E1 and 6' -alkenyl polymyxin E2. The double-bonded polymyxin E component may have antibacterial activity or toxicity different from that of common polymyxin E components, and has potential application value, and the structural confirmation of the compound also provides a research basis for strictly controlling the quality of polymyxin E. |
| priorityDate | 2019-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.