http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110845369-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 |
| filingDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110845369-B |
| titleOfInvention | Synthetic method of dapoxetine and intermediate thereof |
| abstract | The invention discloses a dapoxetine and an intermediate thereof, namely a synthetic method of (S) -3- (tert-butoxycarbonyl) amino-3-phenyl propanol shown in a formula 5, wherein the synthetic method of (S) -3- (tert-butoxycarbonyl) amino-3-phenyl propanol is shown in the following synthetic route, wherein a compound 3 is subjected to Mannich reaction with acetaldehyde in an organic solvent under the action of a chiral catalyst and a supramolecular catalyst constructed by a polymer to obtain a compound 4; the polymer is selected from at least one of the following: PEG200, PEG400, PEG600, MeOPEG750, PEG800, PEG1000, PPG800, PPG 1000. The dapoxetine is synthesized from the (S) -3- (tert-butoxycarbonyl) amino-3-phenyl propanol prepared by the method according to the steps shown in the synthetic route. The synthesis method of dapoxetine and the intermediate thereof has the characteristics of cheap and easily available raw materials, high yield, low cost and more contribution to industrial production. |
| priorityDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.