| abstract |
The invention discloses an application of MIT and/or DIT as thyroid cancer markers and a kit. MIT and DIT are synthetic precursors of thyroid hormone T4, and have stable and constant expression in thyroid tissue, high specificity and effectiveness. The application discovers that the expression levels of MIT and DIT are very different in thyroid cancer tissues and thyroid normal tissues for the first time, and the expression levels of MIT and DIT in thyroid cancer tissues are 200-fold lower than the expression levels in normal tissues. Based on the above, MIT and DIT can be used as biomarkers for thyroid cancer detection, and corresponding analysis methods can be used for preparing a thyroid cancer detection kit, so that a new technical means is provided for thyroid cancer detection, diagnosis, treatment and prognosis evaluation. The kit can realize accurate analysis of thyroid cancer samples collected by the puncture needle and realize the purpose of ultra-efficient and high-sensitivity detection of the kit. |