http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110819657-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-20252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-20262 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-20221 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-20243 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110819657-B |
| titleOfInvention | A kind of preparation method and application of attenuated baculovirus |
| abstract | The present disclosure relates to a preparation method and application of an attenuated baculovirus. Specifically, the present disclosure provides a method for preparing an attenuated viral vector, by which an attenuated RNA virus recombinant expression vector system that chimerically expresses an antibody against a specific target can be prepared, for example, an attenuated RNA virus targeting the tumor microenvironment. Viral vector system. The aforementioned vector systems can stably express the corresponding antibodies against specific targets. The vector of the present disclosure has a wide range of host cells, which greatly improves the expression efficiency of exogenous chimeric antibody-like antibodies in vivo and in vitro; at the same time, the vector system itself has a simple and stable genome, a low mutation rate, and can be embedded quickly and efficiently. Co-express human specific antibodies. In addition, the vector system of the present disclosure reduces the toxicity of the virus due to the genetic mutation modification, and does not cause obvious damage to the normal cells of the host when the antibody is expressed. |
| priorityDate | 2018-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.