http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110812497-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110812497-B |
| titleOfInvention | Bionic Janus magnetic-mesoporous silica nanoparticle for specifically capturing CTCs, and preparation method and application thereof |
| abstract | The invention discloses a bionic Janus magnetic-mesoporous silica nanoparticle for CTCs specific capture, and a preparation method and application thereof. The preparation method comprises the following steps: 1) preparing carboxylated Janus magnetic-mesoporous silica nanoparticles; 2) preparing a fused cell membrane; 3) and coating the prepared fused cell membrane on the surface of the Janus magnetic-mesoporous silica nanoparticle to obtain the bionic Janus magnetic-mesoporous silica nanoparticle. The core Janus magnetic-mesoporous silica nanoparticle has an asymmetric structure and a rod-like shape, and has a large specific surface area; by coating the fused cell membrane on the surface, the characteristic that leucocytes cannot be aggregated in a circulating system can be used, the nonspecific adsorption to blood cells can be reduced, and the method can be well applied to the detection of CTCs. |
| priorityDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.