| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_89d8e7355750aa815842a3fa5b382c19 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 |
| filingDate |
2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_146569a2fb70ae1f1267b584e69cfb10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe0c6b7de37a0a289e22c612bddf2fd4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c479ebf25ee4ef385716d8de92f35c25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_783232be97d60b35c8d7bb3531aafdb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19de8e10a9d9d9365aec2f6926cc641a |
| publicationDate |
2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110812489-A |
| titleOfInvention |
Dual-stage targeting polymer prodrug for treating acute kidney injury and preparation method |
| abstract |
The invention discloses a double-stage targeted macromolecular prodrug for treating acute kidney injury and a preparation method, and belongs to the field of medicine. The polymer prodrug is grafted from (4-carboxybutyl) triphenylphosphonium bromide, curcumin and low molecular weight chitosan with different degrees of polymerization. The polymer prodrug binds to the Megalin receptor specifically expressed on the surface of renal tubular epithelial cells through low molecular weight chitosan to increase the distribution of curcumin in target cells; Under the mediation of (4-carboxybutyl)triphenylphosphine bromide, the distribution of curcumin in the mitochondria of target cells is further increased, and the oxidative stress damage of renal tubular epithelial cells can be effectively reversed by reducing the ROS generated by mitochondria, achieving Targeted therapy for renal ischemia-reperfusion injury. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114573729-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112315953-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112315953-A |
| priorityDate |
2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |