http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110812472-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-53 |
| filingDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110812472-B |
| titleOfInvention | Application of E3 ubiquitin ligase stub1 in inhibition of hepatitis B virus replication |
| abstract | The invention discloses an application of E3 ubiquitin ligase stub1 in inhibiting the replication of hepatitis B virus, and relates to the field of biomedicine. The application refers to the E3 ubiquitin ligase stub1 gene or the E3 ubiquitin ligase stub1 gene The application of the expression product in inhibiting the replication of hepatitis B virus. The E3 ubiquitin ligase stub1 provided by the present invention can ubiquitinate the substrate protein of HSP90, combine with the hepatitis B virus core protein HBc, shorten its half-life, down-regulate the capsid protein, effectively inhibit the replication of the hepatitis B virus, and make up for the Capsid protein inhibitors such as HAPs and other drugs have the disadvantages of fast metabolism and short half-life, and have good application prospects in inhibiting and clearing hepatitis B virus. Moreover, because the E3 ubiquitin ligase stub1 needs to form a conformation with HSP70 and HSP90 and degrade the capsid protein of hepatitis B to function, HSP90 inhibitors can enhance its function and exert a similar function of stub1. |
| priorityDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.