http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110804178-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2019-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110804178-B |
| titleOfInvention | Nano drug-loaded system with glutathione responsiveness and preparation method and application thereof |
| abstract | The invention discloses a nano drug-loaded system with glutathione responsiveness and a preparation method and application thereof. The invention provides a preparation method of a polyester amide polymer PEA with glutathione responsiveness, which comprises the following steps: phenylalanine or salt thereof, dihydric alcohol and p-toluenesulfonic acid are put into a solvent to react under the reflux condition to obtain a graft polymer Phe-6; dissolving cystine or cysteine or derivatives thereof and a polymer Phe-6 in chloroform, adding triethylamine, and stirring for 15-120 min under the condition of ice-water bath to obtain a mixed solution; dropwise adding equimolar diacid chloride diluted by chloroform into the mixed solution, and carrying out an amide reaction for 10-120 min. The glutathione sensitive polymer can lead the drug-loaded nanoparticles to be quickly disintegrated and the encapsulated drug to be quickly released, has high drug-loaded quantity and high responsiveness, has the characteristics of high-efficiency tumor targeting and high-efficiency inhibition of tumor cell growth, reduces the toxicity of chemotherapeutic drugs to normal tissues, and is green and safe. |
| priorityDate | 2019-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.