http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110804055-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2019-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110804055-B |
| titleOfInvention | Preparation method of tadalafil impurity G |
| abstract | The invention discloses a preparation method of tadalafil impurity G. The preparation process comprises the following steps: s1, reacting a compound 6 with an ammoniation reagent and splitting to obtain a compound 7; s2, compound 7 and piperonalPerforming Pictet-Spengler reaction to obtain a compound 8; s3, carrying out acylation reaction on the compound 8 to obtain a compound 9; s4, carrying out cyclization reaction on the compound 9 and the methylamine to obtain a compound 10, and then removing a protecting group to obtain an impurity G; wherein the structures of the compound 6, the compound 7, the compound 8, the compound 9, the compound 10 and the impurity G are shown below. The materials adopted by the preparation method are cheap and easily available, expensive materials and reagents are hardly used in the whole preparation process, and the finished product has obvious advantages, namely each chemical unit in the preparation method is simple to operate, the experimental conditions are mild, harsh experimental conditions are not needed, and the post-treatment is simple; the conversion rate of each step of reaction is high, the yield is high and can almost exceed 80%, and the reaction purity of each step is high and reaches more than 95%, so that the method is suitable for large-scale production and preparation. |
| priorityDate | 2019-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.