http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110804039-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110804039-B |
| titleOfInvention | A class of phthalimide-containing 1,8-naphthalene anhydride derivatives, their pharmaceutically acceptable salts and their antitumor drug applications |
| abstract | The invention discloses a class of phthalimide-containing 1,8-naphthalene anhydride derivatives, a preparation method and application thereof, and belongs to the field of bio-organic synthesis. The phthalimide-containing 1,8-naphthalene anhydride derivatives of the present invention is a phthalimide pharmacophore with anticancer activity introduced on the 1,8-naphthalene anhydride, so as to improve the molecular Antitumor activity and selectivity. The preparation method of the phthalimide-containing 1,8-naphthalene anhydride derivatives of the present invention is to replace the Br at the end of the naphthalene anhydride with piperidinyl to synthesize 4-piperidinyl-1,8-naphthalene Anhydride, to improve its biological activity, the naphthalene imide parent and the phthalamide pharmacophore substituted with different chain amino N-substituted phthalamides are linked together by esterification reaction with alcohol amine as the bridge chain, and the structure and effect of the drug molecule are studied. A class of phthalimide-containing 1,8-naphthalene anhydride derivatives with inhibitory effect on tumor cell growth in vitro was synthesized. |
| priorityDate | 2019-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.