| abstract |
The present invention provides a kind of tetrahydrobenzofuran Mannich base compound, and the structural formula of this kind of compound is: Described R is hydrogen or methyl; R 2 and R 3 include methyl, ethyl, n-propyl, isopropyl, n-butyl, hydroxyethyl, C4 or C5 methylene chain, containing N atom either of the C4 or C5 methylene chains. Its preparation method uses cuprous iodide as a catalyst, dimethyl sulfoxide as a solvent, takes formaldehyde aqueous solution (preferably 30% formalin solution), secondary amine and furanocyclohexanone oxime ethers as raw materials, and uses "one pot". A series of long-chain tetrahydrobenzofuranocyclohexanone Mannich bases have been prepared by the "method" reaction. The reaction product is single, without side reactions, and has good functional group tolerance. Secondary amines containing hydroxyl and heteroatoms have no effect on the reaction. influences. In the present invention, the prepared product is applied to an anti-gastric cancer drug, and remarkable effects are achieved. |