http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110804026-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 |
| filingDate | 2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110804026-B |
| titleOfInvention | Synthesis method of 1- (3- (3- (4-chlorphenyl) propoxy) propyl) piperidine hydrochloride |
| abstract | The invention discloses a method for synthesizing 1- (3- (3- (4-chlorphenyl) propoxy) propyl) piperidine hydrochloride, which comprises the following processing steps: s1, preparing a 3- (4-chlorphenyl) propane-1-alcohol solution and a 3- (piperidine-1-yl) propionic acid solution respectively; s2, respectively feeding a 3- (4-chlorphenyl) propyl-1-alcohol solution and a 3- (piperidine-1-yl) propionic acid solution into a reactor through a metering pump at a certain temperature, and simultaneously adding solid superacid for reaction to prepare a 3- (4-chlorphenyl) propyl 3- (piperidine-1-yl) propionate toluene solution; s3, evaporating the solvent of the toluene solution of the 3- (4-chlorphenyl) propyl 3- (piperidine-1-yl) propionate to obtain 3- (4-chlorphenyl) propyl 3- (piperidine-1-yl) propionate; s4, adding a reducing agent and a catalyst into 3- (4-chlorphenyl) propyl 3- (piperidine-1-yl) propionate, heating to 50-70 ℃, and reacting for 4-8 hours to obtain the target product 1- (3- (3- (4-chlorphenyl) propoxy) propyl) piperidine hydrochloride. The invention has low cost and high yield. |
| priorityDate | 2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.