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filingDate 2018-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6b06d003df1e6c0059f6a8bb62108f5
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publicationDate 2020-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110785429-A
titleOfInvention Methods of increasing protein half-life
abstract The present invention relates to a method for increasing the half-life of a protein by substituting one or more lysine residues present in the amino acid sequence of the protein, or a protein with an increased half-life, wherein the protein having the substituted lysine residues of the present invention remains in the protein for a long time. In the human body, and the treatment effect is excellent. The proteins of the present invention are epidermal cell growth factor, platelet-derived growth factor A and platelet-derived growth factor B, granulocyte-macrophage colony-stimulating factor, follicle stimulating hormone alpha, follicle stimulating hormone beta and angiopoietin 1.
priorityDate 2017-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID14208651
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8HYE5
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7010578
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID399480
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7010580
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100001424
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9DEV3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ71U07
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9DGG5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP04186
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID34420
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7010718
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9795637
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID11600
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID105090400
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415827147
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID21926
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID213
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0A5G2QPN5
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7408078
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01588
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID411621213
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8ID50
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP58343
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO93566
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID414016120
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415784472
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID444876
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO12980
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID36337
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7015689
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID374258
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID280784
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426776694
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1HFN3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP13391
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID108180329
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID751795
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP22077
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID118293
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426792813
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7015695
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426792814
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7015704
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426792817
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP58756
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO13188
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID497229
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP48199
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415785572
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID18792
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID457408
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP48248
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218178
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218184
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218190
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7016045
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO35460
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6993081
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9N2J0
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218191
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7408624
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218195
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2690
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2155
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7016065
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID416129862
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID21839149
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID30546
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID25728
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2691
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7016067
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2158
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCF1S1F8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9GKA1
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218204
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID280805
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426222526
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9GKA2
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7016078
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID85302
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426222531
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7016080
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID16657136
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426152215
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP22589
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18218212
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9GL60
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP06579
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7016082

Total number of triples: 1041.