| abstract |
The present invention provides a low-molecular-weight sea cucumber glycosaminoglycan, which is composed of glucuronic acid group, N-acetylgalactosamine group, fucosyl group and sulfate group or acetyl ester group thereof. Glucuronic acid and N-acetylgalactosamine are interconnected through β(1-3) and β(1-4) glycosidic bonds to form the main chain of the disaccharide repeating structural unit, and the fucosyl group is connected to the main chain in the form of side chains In terms of molar ratio, the ratio of glucuronic acid group: N-acetylgalactosamine group: fucosyl group is 1:(0.8～1.2):(0.6～1.2); In the structure of low molecular weight sea cucumber glycosaminoglycan 10% to 30% of the 2-position of the glucuronic acid group is modified by sulfate groups, the rest are hydroxyl groups, 10% to 30% of the 2-position of the fucose group is modified by acetyl ester groups, and the rest are hydroxyl or sulfate groups. base. The low-molecular-weight sea cucumber glycosaminoglycan of the invention has the functions of anti-inflammatory, anti-vascular disease, anti-tumor or anti-tumor metastasis and improving learning and memory ability, and can be used for preparing related medicines or health-care products. |