http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110776489-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-28 |
| filingDate | 2019-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110776489-B |
| titleOfInvention | Synthesis method of intermediate for preparing cephalotaxine |
| abstract | The invention discloses a synthetic method of an intermediate for preparing cephalotaxine. The technical scheme takes cyclopentadienyl sodium and methyl 3-bromopropionate as initial raw materials, and N-2- (3, 4-methylenedioxyphenethyl) -3- (4-methoxymethyl-1-cyclopentenyl-1-propyl) amine is synthesized through 6 steps of reactions of nucleophilic addition, hydroboration oxidation, hydroxyl protection, reduction, oxidation and reductive amination. As a brand new synthesis route of the intermediate, the method has the advantages of mild reaction conditions, simple operation, cheap and easily-obtained raw materials and higher reaction yield, and the total yield of the method can reach 33.4 percent as shown by experimental verification. In conclusion, the method not only fills up the technical blank of the synthetic method of the N-2- (3, 4-methylenedioxyphenethyl) -3- (4-methoxymethyl-1-cyclopentenyl-1-propyl) amine, but also has outstanding technical advantages in the aspects of cost, yield, reaction conditions and the like. |
| priorityDate | 2019-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.