http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110772483-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2019-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110772483-B |
| titleOfInvention | Application of hydrogen sulfide-modified mesenchymal stem cell extracellular vesicles as miRNA delivery vehicles in hypoxic-ischemic brain injury |
| abstract | The present invention provides the application of hydrogen sulfide-modified mesenchymal stem cell extracellular vesicles as miRNA delivery carriers in hypoxic-ischemic brain injury. The present invention finds and confirms for the first time that using H 2 S to pretreat MSCs extracellular vesicles can effectively improve the curative effect of miR-7b-5p in hypoxic-ischemic brain injury. Specifically, the present invention finds through research that H 2 S-EVs can be used as a natural and excellent carrier of miR-7b-5p to play a better neuroprotective effect in hypoxic-ischemic brain injury; at the same time, by inhibiting target genes The expression of FOS can effectively alleviate HI-induced brain injury and related neuroinflammation. |
| priorityDate | 2019-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.