http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110759907-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8eaf0e75177d288022d3cbabcc3ceada |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2019-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c510829ac21883b5daafa1c4b48eb926 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65fba436856471bc6991be71e68ed3db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_981165bc2faff64ce13240a31412c430 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b20fc41ae67cab8caaabba1d174a23a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc94f2a0cd66b78e5be53ff272a3d20d |
| publicationDate | 2020-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110759907-A |
| titleOfInvention | 7-Azaindole-nitroxide regioselective deoxythiolation |
| abstract | The invention relates to the fields of organic synthesis and pharmaceutical chemical industry, in particular to an iodine-catalyzed 7-azaindole-nitrogen oxide regioselective deoxygenation thioreaction method. In order to overcome the problems of high toxicity, low efficiency and poor adaptability existing in the prior art. The technical scheme adopted in the present invention is to use 7-azaindole-nitrogen oxides as substrates and internal oxidants, and disulfides as thioetherification reagents, and the molar ratio is 1:(0.5～2) condition , adding molecular iodine as a catalyst to carry out deoxythioetherification reaction in a solvent, the amount of solvent is 2～10mL, and the molar concentration of 7-azaindole-nitroxide is 0.1～0.5mol/L; the measured reactant is Add them into the pressure-resistant tube equipped with magnetrons in turn, close the pressure-resistant tube, stir on a magnetic stirrer at room temperature, react at 0.1 MPa and 80-120 ° C for 12-36 h, cool to room temperature, extract several times, and combine The organic phase, solvent removal, and purification yielded the 7-azaindole sulfide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111303117-A |
| priorityDate | 2019-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.