http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110759894-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa9d66b838a3e187f208c5c40d0d7972 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_740dc33f115c808c3535949f86ea85e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35ae347e4042a8733376a1e808b841f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c71b148e6d1ebf9b5daa5442ac11b540 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce935d4ed650fb7d1bf1044b0a901ea4 |
| publicationDate | 2020-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110759894-A |
| titleOfInvention | Synthetic method of 2-aryl indole derivative |
| abstract | The invention discloses a new synthesis method of a 2-aryl indole derivative, which comprises the following steps: in an organic solvent, to N - (2-pyrimidine) indole compounds and aryl silane compounds are used as raw materials, a catalyst, an oxidant and an activator are used as a catalytic system, heating reflux is carried out under stirring, tracking detection is carried out by TLC (thin layer chromatography) until the reaction is complete, and reaction liquid is subjected to post-treatment to obtain 2-arylation indole derivatives; the main catalyst is metal cobalt salt, the oxidant is copper acetate, and the activator is potassium fluoride or cesium fluoride. The method adopts cheap metal cobalt for catalysis, realizes the oxidative coupling reaction between indole derivatives and aryl silane, prepares a series of functionalized 2-aryl indole compounds, enriches the synthesis methods of the skeleton structures, and provides a new synthesis method which is cheaper, easy to obtain and environment-friendly for the synthesis of the 2-aryl indole compounds. |
| priorityDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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