http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110755637-B
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6935 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 |
filingDate | 2019-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-110755637-B |
titleOfInvention | Glutathione inhibitor-photosensitizer co-assembled nanoparticles and construction thereof |
abstract | The invention belongs to the field of new auxiliary materials and new dosage forms of medicinal preparations, and relates to construction of glutathione inhibitor-photosensitizer co-assembled nanoparticles. Wherein, the molar ratio of the glutathione inhibitor to the photosensitizer is as follows: 5: 1-1:5, and is prepared by the following method: dissolving a certain amount of glutathione inhibitor and photosensitizer or a mixture of the glutathione inhibitor and PEG into a proper amount of organic solvent, slowly dripping the solution into deionized water under the condition of stirring, and spontaneously forming uniform nanoparticles. In the nano-drug delivery system, the particle size of the nano-particles is small and uniform, which is beneficial for the nano-particles to be enriched on tumor parts through permeation and retention Enhancement (EPR) effects; the clopidogrel used as a novel glutathione inhibitor can enhance the ROS level and has a synergistic anti-tumor effect with a photosensitizer. |
priorityDate | 2019-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 263.