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filingDate 2018-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea05ba0e052a597cc91bbc2641b35c92
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publicationDate 2020-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110755416-A
titleOfInvention Application of loureirin A in preparing medicine for preventing or treating diabetic angiopathy
abstract The invention discloses an application of loureirin A in preparing a medicament for preventing or treating diabetic vasculopathy. The invention is based on the invention and creation provided by the inventor for the first time to discover that the loureirin A has obvious curative effect on diabetic vascular lesions caused by vascular endothelial injury caused by methylglyoxal. Methylglyoxal is a highly active toxic metabolite of glucose, which is highly increased in diabetic patients, especially in diabetic complications, and is more pronounced. The curative effect of the loureirin A on the diabetes vasculopathy caused by the endothelial injury caused by the methylglyoxal is embodied in the aspects of improving the cell morphology, improving the cell survival rate, reducing the apoptosis rate, relieving the oxidative stress injury of the cells, clearing the methylglyoxal, reducing the content of a glycosylation end product and the like.
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