http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110746598-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110746598-B |
| titleOfInvention | Completely degradable GSH/ROS double-sensitive polymer and preparation method and application thereof |
| abstract | The invention discloses a GSH/ROS double-sensitive polymer capable of being completely degraded, and a preparation method and application thereof. The invention successfully synthesizes a novel carrier material polymer Cys-0E with an oxalate-like ester bond and a disulfide bond by taking natural cystine ester containing a disulfide bond and oxalyl chloride as raw materials; the polymer material can be successfully assembled into a nano-targeting delivery system for efficiently loading various hydrophilic and hydrophobic drugs. The drug-loaded nanoparticles constructed by the nano precipitation method have obvious GSH/ROS dual responsiveness, small particle size, high drug loading capacity, good in-vivo stability and specific targeting on tumors; under the action of tumor redox environment, the carrier is completely degraded, and the entrapped drug is quickly and massively released, so that the effect of efficiently inhibiting tumors in vivo and in vitro is achieved. Meanwhile, the invention has the advantages of simple synthesis, convenient application, environmental protection and no way in the field of biological medicine. |
| priorityDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.