| abstract |
The invention discloses a natural polymer hydrogel based on collagen and a preparation method thereof, belonging to the field of hydrogels. The invention firstly synthesizes a glycogen derivative used as cross-linking agent guanidino glycogen oxide, the glycogen derivative has a plurality of groups on the surface, inorganic component hydroxyapatite and organic component collagen can be connected through chemical bonds and electrostatic action, natural polymer materials and inorganic materials can be combined and used together, and thereby, the hydrogel which can effectively and directionally induce the differentiation of MSCs is formed. The natural polymer hydrogel material based on collagen prepared by the invention has certain stretchability, elasticity and bendability, the compression modulus and the elastic modulus are in the range of the interval capable of differentiating the bone marrow mesenchymal stem cells into cartilage and osteogenesis, and the natural polymer hydrogel material can be ensured not to be easily damaged when large bone injury is faced. |