| abstract |
The invention discloses an aromatic compound and a preparation method and application thereof, wherein the preparation method of the aromatic compound comprises the following steps: in the presence of a rhodium catalyst, a metal oxidant and a base, carrying out cyclization reaction on an amide compound and a benzoic acid compound; wherein the aromatic compound is isoquinolone compound or isocoumarin derivative, and the amide compound is N-vinylformamide or N-vinylacetamide. Through the rhodium catalysis and the synergistic action of the metal oxidant and the alkali, the benzoic acid compound and the amide compound can react in one step to obtain the isoquinolone compound and the isocoumarin derivative. The reaction is simple to operate, the raw materials are cheap and commercially available, reaction substrates can be flexibly selected according to the required isoquinolone compounds and isocoumarin derivatives, and the synthesized isoquinolone compounds and isocoumarin derivatives can be used as skeleton structures existing in a plurality of bioactive molecules and natural products and have strong practicability. |