http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110736828-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48df6bc4ebf937c660e36d97dec66663 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2878 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6839 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-487 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate | 2019-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cd9db25b8728c852ef82b7d52eab020 |
| publicationDate | 2020-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110736828-A |
| titleOfInvention | The role of OPTN mutation leading to abnormal ubiquitination and degradation of OPTN in neuronal injury and its verification method |
| abstract | The invention provides an effect of OPTN mutation leading to abnormal ubiquitination and degradation of OPTN in neuron damage, including: a. Hrd1 mediates the effect of ubiquitination and degradation of OPTN in neurons; b. OPTN mutation has the effect of in vivo protein ubiquitination The role of aberrant degrading of autophagy in neurons; c. The effect of OPTN mutation on autophagy in neurons. The invention provides the effect of OPTN mutation leading to abnormal OPTN ubiquitination and degradation in neuron injury and its verification method, which clarifies the effect of overexpressing WT and E478G mutant OPTN on neuron function, and clarifies that intervention Hrd1 regulates OPTN ubiquitin The effect of chemical degradation on neurons. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111141912-A |
| priorityDate | 2019-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.