http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110724115-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135 |
| filingDate | 2019-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110724115-B |
| titleOfInvention | Method for preparing 2-amino-5-substituted-1, 3, 4-thiadiazole |
| abstract | A method for preparing 2-amino-5-substituted-1, 3, 4-thiadiazole. Adding choline chloride and urea in a formula amount into a reaction container, and stirring at 80 ℃ to obtain a colorless transparent solution, namely a eutectic solvent DES; cooling to room temperature, adding the carboxylic acid and the thiosemicarbazide according to the formula ratio, slowly heating, reacting at 80 ℃, and monitoring by TLC until the reaction is finished; and cooling the reaction mixed solution to room temperature, adding ammonia water into the mixed solution under ice-bath cooling to adjust the pH value to 8-9, separating out a solid, performing suction filtration, washing a filter cake with ice water, and drying to obtain the 2-amino-5-substituted-1, 3, 4-thiadiazole. The eutectic solvent is recovered from the filtrate and can be reused. The method has the advantages of simple operation, simple post-treatment, short reaction time, high efficiency, recyclable catalyst, environmental protection, reduced cost and no need of organic solvent, and is a method for efficiently synthesizing the 2-amino-5-substituted-1, 3, 4-thiadiazole. |
| priorityDate | 2019-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.