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filingDate 2019-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110724087-B
titleOfInvention Organic long-afterglow compound and preparation method and application thereof
abstract The invention discloses an organic long afterglow type compound and a preparation method and application thereof, belonging to the technical field of photodynamic therapy. The invention designs and synthesizes an organic long afterglow class compound with a brand new structure based on oxygen group elements, and has the following advantages: 1. the imaging time is long, and is improved from nanosecond imaging of the traditional fluorescence imaging agent to millisecond imaging of the organic long afterglow material; 2. introducing oxygen group elements into the organic long afterglow compounds improves the yield of the triplet excitons of molecules and promotes the generation of active oxygen; 3. the excitation can be extended to visible light, so that a better treatment effect can be easily achieved under the irradiation of the visible light, and the biological toxicity is low; 4. has good biocompatibility. Experiments prove that the compound has obvious inhibitory activity on gram-positive bacteria, so the compound has the potential of being used as a photosensitizer for effective photodynamic therapy.
priorityDate 2019-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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