http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110713921-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M33-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M41-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00 |
| filingDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110713921-B |
| titleOfInvention | A set of in vitro dynamic drug metabolism incubation system |
| abstract | The invention belongs to the technical field of medicine, and relates to a set of in vitro dynamic drug metabolism incubation system. The system is composed of an incubation system with drug metabolism enzymes, a constant temperature device, a peristaltic pump, an effector cell system and a sampling system, and performs serial circulation perfusion; wherein , the incubation system uses a hydrogel with a temperature-sensitive 3D structure as a carrier to encapsulate microsomes, recombinant enzymes, or liver cells with metabolic capabilities, plus reactive substances such as activation factors; the sampling system consists of a semi-permeable membrane. The dialysis system is constructed to perform real-time free state sampling. This system fully considers the diffusion of drugs in a dynamic environment, the distribution and transport in the system, the combination and reaction with metabolic enzymes, and the final impact on the effector cells. The present invention is suitable for estimating the pharmacokinetic parameters of the drug in the body, the clearance rate CL and the inhibition rate constant Ki, Kinact, KI, etc., truly reflecting the pharmacokinetics (PK), drug interaction (DDI) and drug Dynamics (PD). |
| priorityDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.