| abstract |
The invention relates to a method for preparing alkynols in the technical field of chemical industry, which is characterized in that, in ethanol and formate, under the catalysis of iridium catalysts of chiral spirocyclic pyridylamino phosphine ligands, the alkynones are made asymmetrically Catalytic transfer hydrogenation affords chiral alkynols with high optical purity. The method avoids the use of bases in the hydrogenation reaction, the solvent is regenerable, and the optically active chiral alkynols can be obtained with very high enantioselectivity and yield under low catalyst consumption. Selectivity, economy, good operability, environmental friendliness, recyclable catalyst and new method suitable for industrial production. |