http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110687217-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110687217-B |
| titleOfInvention | Method for measuring rifamycin S by liquid chromatography |
| abstract | The invention relates to a method for quantitatively analyzing rifamycin S which is a synthetic raw material of rifampicin by using liquid chromatography, belonging to the field of chemical analysis. The method comprises the following steps: firstly, preparing a standard solution of a rifamycin S standard substance by using a buffer solution; secondly, treating the cyclization reaction solution: adding the crude product into an acetic acid solution, carrying out suction filtration to obtain a solid product containing the rifamycin S, adding acetonitrile for dissolving, carrying out volume metering by using a buffer solution, and then carrying out filtration and impurity removal by using a microporous filter membrane to obtain a liquid chromatography detection sample; thirdly, performing liquid chromatography analysis on the standard solution, and drawing a standard curve; and fourthly, analyzing the sample by using liquid chromatography, and comparing with a standard curve to determine the content of the rifamycin S which is the raw material for synthesizing the rifampicin after the cyclization reaction. The method can accurately determine the content of rifamycin S as a raw material for synthesizing rifampicin and the reaction conversion rate, and fills the defects of the prior art. |
| priorityDate | 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.