http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110684036-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 |
| filingDate | 2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110684036-B |
| titleOfInvention | Method for preparing eribulin mesylate |
| abstract | The invention relates to a preparation method of eribulin mesylate. The reaction involves reacting 2- [ (2S) -2-benzoyloxy ] -3- [ (2R,3R,3aS,7R,10S,11S,12S,13R,14S,15S,16E,21S,24S,27S,29R,31R,32aS) -12,13, 15-tris [ [ (1, 1-dimethylethyl) dimethylsilyl ] oxy ] -3,3a,4,5,6,7,8,9,10,11,12,13,14,15,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,32 a-triacontahydro-3-methoxy-29-methyl-23, 30-bis (methylene) -5, 18-dioxy-7, 11:10,14:21,24:27, 31-tetracyclooxy-2H-cyclotriundec [ b ] furan-2-yl ] propane The group ] -1H-phthalimide (N-ERBL-05) is used as an intermediate, and the eribulin mesylate is prepared through three steps of reactions. |
| priorityDate | 2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.