| abstract |
The invention belongs to the field of pharmaceutical synthesis, in particular to a preparation method of a carboxylic acid aryl ester compound. The preparation method provided by the present invention includes: providing a compound A represented by formula a, a compound B represented by formula b, an organic palladium complex, and a silver salt; the organic palladium complex is compounded by a palladium compound and a nitrogen-containing ligand Formation, nitrogen-containing ligands include: o-phenanthroline compounds and/or bipyridine compounds; compound A, compound B, organic palladium complex and silver salt are mixed in a reaction solvent, and carried out under an inert gas atmosphere The reaction is carried out to obtain the carboxylic acid aryl ester compound represented by formula I. This method uses both organopalladium complexes and silver salts to realize the direct and selective C-O coupling of carboxylic acids and halogenated aromatic hydrocarbons. It is suitable for a variety of carboxylic acid substrates and halogenated aromatic hydrocarbon substrates, with wide compatibility and high yield high. |