| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78160fe5924d399deb065f8cbc5ad347 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-443 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-34 |
| filingDate |
2019-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_109cbe76fa1cdee8726a348758e7f9a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_502af570c40e9b6d02857b4c0b4df4f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f82fef8b68932778da4ae3ce8c06b03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b622cb7f4650e327d87c5ab2b6604dc8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_489c8f316db26ae42c2c03dd3c81cea4 |
| publicationDate |
2020-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110680926-A |
| titleOfInvention |
A kind of nano-diagnostic agent and its preparation method and application |
| abstract |
The invention relates to a nano-diagnostic agent and a preparation method and application thereof, wherein the preparation method comprises the steps of: mixing and culturing glucose oxidase (GOx) or modified GOx with a sugar-free medium and a water-soluble Fenton reagent to prepare GOx complex solution; adding calcium salt to the GOx complex solution, and reacting to prepare the nanodiagnostic agent. The preparation process of the nano-diagnostic agent provided by the invention is simple and the operation is convenient. In the nano-diagnostic agent prepared by the present invention, both GOx and calcium phosphate exist in the human body and are easily absorbed and degraded by the human body, and the metal ions in the Fenton reagent are all trace elements required by the human body and have good biological properties. Compatibility and biodegradability, the nano-diagnostic agent prepared by the present invention wraps GOx in a calcium phosphate carrier, which avoids the problem of high blood toxicity caused by direct exposure of GOx. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113368254-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113398095-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114146166-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111388451-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113499430-A |
| priorityDate |
2019-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |