| abstract |
The invention discloses a donepezil-oxadiazole fusion compound, the structural formula of which is shown in formula (I), (II) (III) or (IV). The invention also discloses a preparation method of the above donepezil-oxadiazole fusion compound and the same The invention has novel structure, and has various activities such as inhibitor of cholinesterase, activation of Nrf2 pathway, etc., and can improve the level of acetylcholine in the brain and activate the anti-oxidative stress of cells. reaction. |