http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110668990-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 |
| filingDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110668990-B |
| titleOfInvention | Crystallization method for preparing high-purity monodisperse I crystal form atorvastatin calcium in single kettle |
| abstract | The invention relates to a crystallization method for preparing high-purity monodisperse I crystal form atorvastatin calcium in a single kettle. Adding a mixed solvent consisting of a good solvent and an anti-solvent of atorvastatin calcium into a crystallizer, adding crystal form I atorvastatin calcium crystallization powder into the crystallizer, keeping the temperature of the solution at normal temperature, dispersing crystal particles by using ultrasound, and then heating to the temperature in the elution process; adding two solutions of an anti-solvent and a good solvent for dissolving atorvastatin calcium into the seed crystal suspension at the same time, and keeping the composition of the solvent in the seed crystal suspension in the process basically unchanged; continuously adding an anti-solvent into the crystallizer, and then carrying out heat preservation and suspension; and cooling the solution to normal temperature, filtering, washing with pure water and drying to obtain crystalline powder of atorvastatin calcium crystal form I. The crystal particles of the powder are in the form of long rods, the longitudinal dimension of which is not more than 30 μm and the cross-sectional dimension of which is not more than 5 μm. Short production period, low solvent cost, simple operation and suitability for industrial production. |
| priorityDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.