http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110664821-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95f88d4c381eb8c9a26a527dca86d8a6 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 |
filingDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_617c56caff36171858ab8da50e15b1b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba8cb52756160e8bc879ee73e24158bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e8ea18cc54dce3e4f83685c38afc009 |
publicationDate | 2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-110664821-A |
titleOfInvention | Application of Panaxadiol in the Preparation of Drugs for Inhibiting the Expression of PD-L1 and Tumor Cell Proliferation Proteins |
abstract | The invention provides the application of panaxadiol in the preparation of a drug for inhibiting the expression of PD-L1 protein and tumor cell proliferation protein, and belongs to the technical field of natural small molecule drug application. The panaxadiol in the invention can inhibit PD in a dosed manner The expression of ‑L1 protein, the RNA transcription level of PD‑L1, and the rate of PD‑L1 positive cells; it can also inhibit the expression of hypoxia-induced tumor proliferation-related proteins Cyclin D1, c‑Myc and VEGF in a dose-dependent manner; The number of EdU positive cells can inhibit the proliferation of tumor cells; it can significantly improve the viability of T cells in the co-culture system; it can effectively inhibit the volume of transplanted tumors in nude mice; it can be seen that panaxadiol has a significant effect as a drug for inhibiting colon cancer . |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113264973-A |
priorityDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 234.