| abstract |
Provided are methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for a GIPR polypeptide conjugated to a GLP-1 receptor agonist. In various embodiments, the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels, and diabetic nephropathy. In certain embodiments, the composition comprises an antibody or functional fragment thereof containing a cysteine at one or more conjugation sites, wherein the GLP-1 receptor agonist is via the cysteine residue The side chain of is coupled to the antibody or functional fragment thereof. |