http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110656152-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5456846495c5fa8a02f5eaae9faae290 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5055 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80da314ec6a586cd8ed7c65a6c970aa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26a4b70c8d6d8993192cf50c14345287 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6ef886365a7ba04634a160404247cac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b85274f9a50d74b80af0c2ab0eb872a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_620d34db116ca01280e3738aeb1c6a49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bea58f4956c70c593c714af481801095 |
| publicationDate | 2020-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110656152-A |
| titleOfInvention | A method for verifying the anti-angiogenesis effect of eltrombopag mediated by macrophages |
| abstract | The present invention provides a method for verifying the anti-angiogenesis effect of Eltrombopag (ELB)-mediated macrophages. The effects of ELB on macrophage proliferation and angiogenesis-related factors (VEGF- A. The expression of bFGF, MMP-9) mRNA and the influence of VEGF protein; then through MTT assay, cell scratch assay, Matrigel Matrigel tube formation assay, the effect of ELB on endothelial cell proliferation, migration and tube formation by macrophages was observed Impact. The present invention confirms that ELB can inhibit the proliferation of macrophages, inhibit the expression of angiogenesis-related factor mRNA and the release of VEGF protein, and at the same time find that ELB acting on the supernatant of macrophages can significantly inhibit the proliferation, migration and tubule formation of endothelial cells , indicating that ELB can mediate macrophages and have an anti-angiogenic effect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113355273-A |
| priorityDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.