| abstract |
The present invention relates to bispecific antibodies or antibody mixtures, in particular to bispecific antibodies or antibody mixtures having a common light chain, and methods for preparing the bispecific antibodies or antibody mixtures. The present invention also relates to nucleic acid molecules encoding said bispecific antibodies or antibody mixtures, recombinant vectors and recombinant cells containing said nucleic acid molecules, and methods of detection and quantification of said bispecific antibodies or antibody mixtures. The present invention prepares bispecific antibodies or antibody mixtures by common light chain technology, the preparation method is simple and controllable, and the mismatch of light chains in bispecific antibodies can be avoided, and for antibody mixtures, it can be expressed in the same host cell, It reduces the difficulty of culturing mixed cell groups and is more conducive to scale-up production. |