| abstract |
The invention provides a preparation method of a 6 beta-methyl steroid compound, which comprises the steps of dissolving a compound shown in a formula I in an organic solvent, adding a palladium-carbon catalyst and a monophosphite ligand, and heating and reacting with cyclohexene to prepare a compound shown in a formula II. The invention has the beneficial effects that: by adding the monophosphite ligand into the reaction system, a 6 beta-methyl steroid product with yield of more than 95% can be obtained during reduction reaction, the pure chemical preparation of the steroid 6 beta-methyl compound can be realized, the preparation process does not contain dangerous reagent conditions, and the product has good purity and high yield. |