| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6456
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a780e9de8092c03761d2e939a883c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dd683fe7a37129fab8ad027f9fdaaed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be327c7b82b5d193d9d63ab3babee8c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e22e8dfd602d1dff2a0af1d6db6f6914 |
| publicationDate |
2020-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110655510-A |
| titleOfInvention |
A sulfite ratio fluorescent probe targeting lipid droplets and its application |
| abstract |
The invention discloses a sulfite ratio fluorescent probe targeting lipid droplets based on a corresponding mechanism of fluorescence resonance energy transfer, which uses a coumarin fluorophore as an energy donor and a conjugated carbazole derivative as an energy acceptor. It is connected by a piperazine alkyl chain; its chemical structure is shown in formula (I). The probe of the present invention can selectively interact with sulfite HSO 3 ‑ /SO 3 2‑ , and with the increase of sulfite concentration, its fluorescence emission intensity gradually increases at 470 nm and gradually weakens at 627 nm; The ratio (I 460 /I 627 ) has a linear relationship with the sulfite concentration within a certain range. The intracellular ratiometric imaging is achieved, and the ratiometric fluorescent probe has good targeting to lipid droplets, which is expected to play a role in industrial production and clinical medicine, and has broad application prospects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111171008-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112321570-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111171008-B |
| priorityDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |