http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110646550-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5282af680e794572c17b2eeb5156feb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-74 |
| filingDate | 2018-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e2347cb9a340142f4bee313495c250f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e4f9d3d579c6104af24112aa9fff80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d42a0654bb816c3af926cc655f1c2e61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f44cd64d7019b13bae0c3bf294cb0096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a874e645f9fb1a9ca8374a71925ce50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d930af9720af67e455ccb93f3db7731 |
| publicationDate | 2020-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110646550-A |
| titleOfInvention | A kind of detection method of related substances in atorvastatin calcium |
| abstract | The invention relates to a method for detecting a related substance in atorvastatin calcium, wherein the related substance is atorvastatin calcium acetonide tert-butyl ester (impurity I), and the method comprises the steps of using high performance liquid chromatography to detect, The chromatographic column used in the liquid chromatography is a reverse chromatographic column, and gradient elution is performed with mobile phase A and mobile phase B, and the mobile phase A is solution A and buffer with a volume ratio of 35-45:55-65. A mixed solution of solutions, the solution A is an acetonitrile-tetrahydrofuran solution with a volume ratio of 800～950:50～200, and the mobile phase B is a solution A with a volume ratio of 40～80:10～30:10～50 A mixed solution of buffer solution-methanol, the detection method can fully separate the various components of atorvastatin calcium related substances, and at the same time, the atorvastatin calcium and tert-butyl acetonide, which cannot be detected in the reference method, can also be accurately and effectively The detection of atorvastatin calcium can effectively improve the drug quality and safety of atorvastatin calcium. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114295748-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114384178-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114384178-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113702514-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112782333-A |
| priorityDate | 2018-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.