http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110642862-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2019-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110642862-B |
| titleOfInvention | Preparation method of ticagrelor ethylated impurity |
| abstract | The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of ticagrelor ethylenated impurities. The method mainly comprises 2 steps of esterification and hydrolysis, can obviously improve the conversion rate at a lower temperature by utilizing a mitsunobu reaction principle, does not need column passing, and can remove impurities which are difficult to remove by adopting ether solvents and the like, so that the compound II has higher yield and purity, the complicated operation steps are reduced, the conditions are mild, the production cost is low, and the method is suitable for large-scale industrialized production of ticagrelor ethylenated impurities. The prepared ticagrelor ethylenated impurity can be used for detecting and monitoring the impurity in the process of synthesizing ticagrelor, so that the quality of a ticagrelor raw material medicine is controlled, and the quality of a ticagrelor raw material is improved. |
| priorityDate | 2019-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.