http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110642861-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110642861-B |
| titleOfInvention | PET/CT tracer agent with selectivity on different lung cancer cells and preparation method and application thereof |
| abstract | The invention provides a PET/CT tracer agent with selectivity on different lung cancer cells, a preparation method and application thereof. The PET/CT tracer of the invention is a compound shown in formula I, or a salt or a stereoisomer thereof: wherein R is 1 、R 2 Each independently selected from H or C 1 ‑C 5 Alkyl groups of (a); x is independently selected from 11 C、 18 F、 19 F、 15 O or 13 And N is added. Prepared by the invention 18 F-PET/CT tracer can be selectively taken by different cancer-driving gene mutant lung cancer cells, and test results show that the invention 18 The F-PET/CT tracer agent is expected to be imaged in NRas Q61K tumor model in high quality, has certain selectivity on different oncogene-driven mutant lung cancers, and can cause high-concentration imaging nonspecific imaging with any pathological changes with increased glucose metabolism 18 The difference of F-FDG is expected to make up for the single use 18 Deficiency in F-FDG imaging. Accordingly, the present invention 18 The F-PET/CT tracer is expected to be applied to PET/CT imaging, and changes the situation of tracer deficiency in lung cancer. |
| priorityDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.