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filingDate 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110638846-B
titleOfInvention Application of RNase L inhibitor
abstract The invention discloses application of an RNase L inhibitor, which comprises application of specific compounds in preparation of RNase L inhibitors, oncolytic virus anti-tumor synergists and anti-tumor products and pharmaceutical compositions, wherein the specific compounds have targeted specificity on RNase L. The prepared RNase L inhibitor can effectively inhibit the activity of RNase L, prevent oncolytic virus from being degraded, ensure that the oncolytic virus can be successfully replicated in host tumor cells and kill the tumor cells, and effectively improve the anti-tumor effect of the oncolytic virus. On the basis, the RNase L inhibitor and the specific oncolytic virus can be compounded into an anti-tumor product, so that the normal exertion of the effect of killing tumor cells by the oncolytic virus is ensured.
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