| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-916
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2835
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0662
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate |
2019-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2021-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110628824-B |
| titleOfInvention |
Construction method and application of DJ-1 function-loss cell model |
| abstract |
The invention discloses a construction method and application of a DJ-1 loss-of-function cell model. The construction method of the cell model comprises the following steps: reducing activity and/or expression quantity of DJ-1 protein of the pluripotent stem cells, inhibiting expression of DJ-1 gene of the pluripotent stem cells, or knocking out DJ-1 gene of the pluripotent stem cells to obtain the DJ-1 dysfunction pluripotent stem cells; inducing the DJ-1 loss-of-function pluripotent stem cells to be neural stem cells or mesenchymal stem cells to obtain a cell model; the pluripotent stem cells are embryonic stem cells or induced pluripotent stem cells. The cell model constructed by the invention can be used for preparing the cell model of the Parkinson disease caused by DJ-1 mutation. The invention lays a foundation for disease treatment of pathogenesis of Parkinson's disease and has important application prospect. |
| priorityDate |
2019-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |