http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110628802-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-16 |
| filingDate | 2019-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110628802-B |
| titleOfInvention | Sorangium cellulosum for high-yield epothilone D and construction method and application thereof |
| abstract | The invention discloses sorangium cellulosum for high-yield epothilone D and a construction method and application thereof. The construction of the recombinant sorangium cellulosum So ce M4 strain with the epoK gene knocked out by utilizing the TALEN technology is disclosed for the first time, and experiments prove that the epoK gene in the sorangium cellulosum So ce M4 strain knocked out by utilizing the TALEN technology can obviously improve the yield of epothilone D and simultaneously reduce the yield of epothilone B, thereby realizing the oriented biosynthesis of the epothilone in sorangium cellulosum. The invention discloses the method for improving the yield of epothilone production by sorangium cellulosum by using the TALEN technology for the first time, and the application of the TALEN technology to the improvement of the yield of epothilone D production by sorangium cellulosum can promote the biosynthesis of epothilone while promoting the development of the genetic engineering modification technology of sorangium cellulosum, expand the application of epothilone D in the aspect of tumor resistance, and have very important significance for the development of biological medicines in China. |
| priorityDate | 2019-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.